Endocrine Abstracts

Over the last two decades, our concepts of estrogen action have changed dramatically. From a clinical perspective, recommendations for estrogen replacement therapy have changed from enthusiasm about the benefits of postmenopausal hormone replacement to recognition that long-term estrogen treatment is associated with increased risk of cardiovascular disease, breast cancer, and uterine cancer. From a basic science perspective, the cloning of the estrogen receptor (ER) provided n...